lihlahisoa
Boleng bo phahameng L-Glutathione Fokotse CAS 70-18-8 bakeng sa Tlhokomelo ea Letlalo Glutathione
Lintlha tsa sehlahisoa
MF: C10H17N3O6S
MW: 307.32
CAS: 70-18-8
1.Glutathione ke motsoako oa tripeptide o kopantsoeng ke glutamic acid, cysteine le glycine ka litlamo tsa peptide.Ke mercaptan ea bohlokoa ka ho fetisisa e tlase ea molek'hule liseleng tsa mammalian tlas'a khatello ea antioxidant.
2.Glutathione (GSH) ke motsoako oa tripeptide o entsoeng ke condensation ea glutamic acid, cysteine le glycine ka litlamo tsa peptide.Lebitso la eona la lik'hemik'hale ke γ- Mokhoa oa sebopeho sa l-glutamyl-l-cysteyl-glycine o bontšitsoe setšoantšong sa 1chemicalbook.Ho ea ka moralo oa sebopeho setšoantšong, GSH e fapane le li-peptide le liprotheine tse ling.Ho na le tlamo e khethehileng ea peptide molek'hule ea eona, e entsoeng ka glutamic acid γ- Carboxyl (- COOH) le cysteine α- Peptide bond e entsoeng ka condensation ea amino - (- NH2).
3. Boima ba molek'hule ea glutathione ke 307.33, ntlha ea ho qhibiliha ke 189 ~ 193 ℃ (ho senyeha), kristale ha e na mebala, e hlakileng, e tšesaane, 'me ntlha ea isoelectric ke 5.93.E qhibiliha ka metsing, e hlapolla joala, ammonia ea metsi le methyl formamide, empa ha e qhibilihe ka joala, ether le acetone.Ke GSH feela e nang le ts'ebetso ea 'mele ka har'a lintho tse phelang,' me GSSG e ka bapala ts'ebetso ea eona ea bohlokoa ea 'mele ka mor'a ho fokotseha.GSH ha e bonolo ho e boloka tlas'a ts'ebetso ea metsi a phahameng, 'me e ka bolokoa ka mokhoa o tsitsitseng ka nako e telele feela ha mosebetsi oa metsi o laoloa ka tlase ho 0.3.Liphuputso li bontšitse hore ka vithamine ccchemicalbook aqueous solution e nang le GSH (ph3.3), ka lebaka la ho fokotseha ho matla ha vithamine C, GSH ka tharollo e ke ke ea e-ba oxidized ho GSSG, empa lebelo la eona la ho bola le potlakile;GSSG ka vithamine C tharollo ea metsi e ke ke ea fetoloa GSH, 'me botsitso ba eona ba polokelo bo molemo haholo.Ho feta moo, GSSG e kenngoa ka molomo e ka fokotsoa hore e be GSH karolong e ka holimo ea mala a manyenyane, 'me bokaholimo ba lisele tse nyenyane tsa mala a mala γ- GTP (e leng se senyang GSH ho glutamic acid le Cys Gly) le dipeptidase le tsona li ka bapala karolo ea bohlokoa ea physiological. mesebetsi.
4.Glutathione e teng ka bongata liphoofolong le limela, 'me likahare tsa eona tomosong ea baapehi, kokoana-hloko ea koro le sebete sa phoofolo e phahame haholo, ho fihlela ho 100 ~ 1000mg/100g;E boetse e ruile maling a batho le a liphoofolo, joalo ka 26chemicalbook ~ 34mg/100g maling a motho, 58 ~ 73mg/100g maling a likhoho, 10 ~ 15mg/100g maling a kolobe le 14 ~ 22mg/100g maling a ntja.GSH e boetse e fumanoa merohong e mengata, litapole le lijo-thollo.
Kopo
1.Glutathione e fokotsehileng ke peptide e nyenyane ea molek'hule, e teng ka bongata linthong tse phelang, haholo-holo liseleng tsa sebete.E ka sireletsa lera la lisele tsa sebete, ea khothalletsa tšebetso ea enzyme ea sebete, 'me ea kopana le lik'hemik'hale tse ngata tse chefo ka har'a li-chemicalbook ho tlosa chefo.E na le phello e ntle ho kotsi ea sebete, sebete sa sebete le mafu a mang a bakoang ke chefo ea lithethefatsi, tahi le mabaka a mang.
2.E na le mesebetsi ea antioxidation, scavenging free radicals, detoxification, ho matlafatsa ho itšireletsa mafung, ho lieha ho tsofala, ho thibela kankere, ho senya mahlaseli a kotsi joalo-joalo.
3.Li-reagents tsa biochemical le li-antidotes li sebelisoa haholo-holo bakeng sa chefo ea tšepe e boima, acrylonitrile, fluoride, carbon monoxide le li-solvents tse phelang.
Li-antioxidants tsa 4.Endogenous tse phethang karolo ea bohlokoa phokotsong ea mefuta ea oksijene e sebetsang e entsoeng nakong ea metabolism ea lisele le ho hema ka tšohanyetso.Glutathione-S-transferase e etsa hore ho be le glutathione sulfide e nang le xenobiotics, leukotrienes le limolek'hule tse ling tse nang le litsi tsa electrophilic.Glutathione e boetse e theha maqhama a disulfide le masala a cysteine ka liprotheine.Ka mekhoa ena, e ka ba le phello e makatsang ea ho fokotsa ts'ebetso ea li-anticancer agents.
